Telethon Kids Institute
Development and lineage specificity in Down syndrome leukaemia: a key role for the kinase DYRK1A
Dr Sébastien Malinge is a Senior Research Fellow highly qualified in the field of paediatric leukaemia, with a strong background in the mechanisms of leukaemia predisposition and development in children with Down syndrome. He obtained his PhD in 2006 in France, at Paris children's hospital (Necker-Enfants Malades Hospital), and subsequently joint Northwestern University (Chicago, USA) as a research fellow awarded by the Leukaemia and Lymphoma Society. In 2012, he became an independent investigator at the French National Institute for Health and Medical Research (INSERM), located at Gustave Roussy, one the first Cancer Centre in Europe. In 2017, Dr Malinge relocated to the Telethon Kids Institute - Cancer Centre, as the Children`s Leukaemia and Cancer Research Foundation (CLCRF) – U. Kees fellow, and became co-head of the Leukaemia and Cancer Genetics team in 2018.
Based on a solid background in fundamental research, next generation sequencing and the development of preclinical Patient Derived Xenograft (PDX) models, Dr Malinge is now developing cutting-edge approaches to unravel new vulnerabilities in leukaemia cells, with the view of identifying alternative therapeutic approaches and new effective treatments, to make a tangible difference to the way we treat paediatric leukaemia.