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Professor Glen Ulett

Griffith University


Presentation Title


Implications of Streptococcus urinary tract infection for human health

 Australian Society for Microbiology



Streptococcus agalactiae, a gram-positive bacterium, causes approximately 160,000 cases of urinary tract infection (UTI) in the United States annually. These infections present in various forms, including acute cystitis and pyelonephritis, as well as asymptomatic bacteriuria (ABU). The host-pathogen interactions that occur during S. agalactiae UTI and mechanisms of pathogenesis are increasingly being defined based on in vitro, in vivo, and clinical case studies. In this presentation, I will give an overview of these infections, including the interactions between bladder cells, bladder tissue and uropathogenic S. agalactiae that contribute to acute disease, and the host responses to infection. Recent insights on infection-induced cytotoxicity and the contributions of streptococcal virulence factors, including ?-hemolysin/cytolysin (?-H/C), surface displayed capsular polysaccharide and protein adhesins, and the global virulence regulator CovR, will be discussed. The biology of ABU-causing S. agalactiae strains, including how such strains might colonize the urinary tract via novel metabolic pathways, including the utilization of malate in urine to support microbial growth, will also be discussed. Overall, the presentation will provide an update on these infections and the implications of understanding the pathogenesis of disease for human health.





Last Updated on Wednesday, 16 August 2017 13:20
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